LONDON, Mar 18: Scientists have reversed Type 2 diabetes in a study of patients who underwent intensive medical treatment to control their blood sugar levels.
By following a regimen of strict diet, exercise and medications, up to 40 percent of the participants managed to stay in remission for three months after stopping their medication.
The research was conducted by investigators at McMaster University in Ontario, Canada.
Researchers divided 83 individuals with Type 2 diabetes into three groups. Two of the groups received intensive metabolic intervention that included a personalized meal plan that cut their daily caloric intake by 500 to 750 calories per day. They were also given an individualized exercise plan, met with a dietitian regularly and took medication and insulin at bedtime to help control blood glucose.
The only difference is one group was intensively treated for 16 weeks while the other group received the same intervention for just eight weeks.
They were compared to a third group of participants that was given standard diabetic management information from a health care provider, including lifestyle advice.
All of the participants had their blood glucose measured at 20, 28 and 52 weeks to see how well their blood sugar was controlled.
After eight and 16 weeks of the intensive intervention, medication was stopped in both groups.
In the 16-week group, 11 of 27 participants met the criteria for complete or partial remission of their diabetes for a period of three months after the trial.
In the eight-week intensive therapy group, six out of 28 individuals were in remission for three months after the intervention was completed. Only four out of 28 patients in the control group showed remission.
The results of the study were published in the Journal of Clinical Endocrinology and Metabolism.